Gould E, Watzak L, Chamizo W, Albores-Saavedra J
Department of Pathology, University of Miami School of Medicine, FL 33101.
Acta Cytol. 1989 Jan-Feb;33(1):16-20.
The sensitivity and specificity of nuclear grooves and inclusions for papillary carcinoma was investigated in 32 touch preparations and 69 fine needle aspiration cytologic preparations of the thyroid. Ultrastructurally, these grooves and inclusions are cytoplasmic invaginations into the nucleus. Overall, 100% of the papillary carcinomas contained nuclear grooves while only 70% contained inclusions. Grooves, however, could be seen in 70% of nonpapillary neoplasms and in 56% of nonneoplastic conditions of the thyroid, albeit generally fewer in number and often not as distinct. Inclusions were present in 13% of nonpapillary neoplasms and were absent in nonneoplastic conditions. Some nuclei on cytologic preparations contain lines that are probably artifacts of chromatin alignment and do not represent true nuclear grooves. Since such lines may be indistinguishable from true grooves, grooves should be used cautiously and in conjunction with other criteria in the diagnosis of papillary carcinoma.
在32份甲状腺触诊标本和69份甲状腺细针穿刺细胞学标本中，研究了核沟和核内假包涵体对乳头状癌的敏感性和特异性。超微结构上，这些沟和包涵体是细胞质向细胞核内的内陷。总体而言，100%的乳头状癌含有核沟，而只有70%含有核内假包涵体。然而，70%的非乳头状肿瘤和56%的甲状腺非肿瘤性病变中可见核沟，尽管数量通常较少且往往不那么明显。13%的非乳头状肿瘤中存在核内假包涵体，非肿瘤性病变中则不存在。细胞学标本上的一些细胞核含有线条，这些线条可能是染色质排列的假象，并不代表真正的核沟。由于这些线条可能与真正的核沟难以区分，因此在诊断乳头状癌时应谨慎使用核沟，并结合其他标准。
