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Mesenchymal stem cells derived from human chorionic plate may promote hematopoietic differentiation of the human embryonic stem cell line SNUhES3.

作者信息

Kim Seok Jin, Yoo Ji Hyun, Kim Byung Soo, Oh Jee Hyun, Song Chang Hee, Shin Hye Jin, Kim Sun Haeng, Choi Chul Won, Kim Jun Suk

机构信息

Department of Internal Medicine, Korea University Medical Center, Seoul, Korea.

出版信息

Acta Haematol. 2006;116(3):219-22. doi: 10.1159/000094687.

DOI:10.1159/000094687
PMID:17016045
Abstract
摘要

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Mesenchymal stem cells derived from human chorionic plate may promote hematopoietic differentiation of the human embryonic stem cell line SNUhES3.
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Human bone marrow mesenchymal stem cells expressing SDF-1 promote hematopoietic stem cell function of human mobilised peripheral blood CD34+ cells in vivo and in vitro.人骨髓间充质干细胞表达 SDF-1 可促进体内、外人动员外周血 CD34+细胞造血干细胞功能。
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Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34(+)/CD38(-) early progenitors cultured over human MSCs as a feeder layer.作为饲养层的人骨髓间充质干细胞培养的脐血CD34(+)/CD38(-)早期祖细胞中LTC-ICs的扩增以及p21和BCL-2表达的维持。
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Mesenchymal stem cells feeder layer from human umbilical cord blood for ex vivo expanded growth and proliferation of hematopoietic progenitor cells.用于造血祖细胞体外扩增生长和增殖的人脐带血间充质干细胞饲养层
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Granulocyte-colony stimulating factor and stem cell factor are the crucial factors in long-term culture of human primitive hematopoietic cells supported by a murine stromal cell line.粒细胞集落刺激因子和干细胞因子是由小鼠基质细胞系支持的人类原始造血细胞长期培养中的关键因子。
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引用本文的文献

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Diverse hematopoietic potentials of five human embryonic stem cell lines.五种人类胚胎干细胞系的多样造血潜能。
Exp Cell Res. 2008 Oct 1;314(16):2930-40. doi: 10.1016/j.yexcr.2008.07.019. Epub 2008 Jul 29.