Okada Kana, Okaichi Hiroshige
Department of Psychology, Faculty of Letters, Doshisha University, Karasuma Imadegawa, Kyoto, Japan.
Shinrigaku Kenkyu. 2006 Aug;77(3):261-70. doi: 10.4992/jjpsy.77.261.
This study examined whether the cooperation of the hippocampus, and anterior thalamus via the fimbria-fornix is involved in the spatial memory. We compared the effect of contralateral lesions (Contra) with ipsilateral lesions (Ipsi) of the fimbria-fornix and anterior thalamus on the performance of an object exploration task and the Morris water maze task. If the hippocampus and anterior thalamus take part in a same functional system via fornix, the performance of Contra group will be more disruptive than that of Ipsi group. In the object exploration task, Contra and Ipsi groups did not differ from Control group in the performance of object recognition test. However, the performance of Contra group was significantly impaired in the spatial recognition test, compared with two other groups. In the Morris water maze task, only Contra group showed deficits in spatial learning but not the Ipsi group. These results indicate that contralateral, but not ipsilateral lesion caused deficits in spatial memory, supporting the notion that the functional cooperation of hippocampus and anterior thalamus via fornix is vital for spatial memory.
本研究考察了海马体与前丘脑通过穹窿-海马伞的协作是否参与空间记忆。我们比较了穹窿-海马伞和前丘脑的对侧损伤（Contra）与同侧损伤（Ipsi）对物体探索任务和莫里斯水迷宫任务表现的影响。如果海马体和前丘脑通过穹窿参与同一个功能系统，那么Contra组的表现将比Ipsi组受到更大干扰。在物体探索任务中，Contra组和Ipsi组在物体识别测试的表现上与对照组没有差异。然而，与其他两组相比，Contra组在空间识别测试中的表现显著受损。在莫里斯水迷宫任务中，只有Contra组在空间学习方面表现出缺陷，而Ipsi组没有。这些结果表明，对侧而非同侧损伤会导致空间记忆缺陷，支持了海马体和前丘脑通过穹窿进行功能协作对空间记忆至关重要的观点。
