Aggleton J P, Neave N, Nagle S, Hunt P R
Department of Psychology, University of Durham, UK.
Behav Brain Res. 1995 Apr;68(1):91-101. doi: 10.1016/0166-4328(94)00163-a.
The effects of cytotoxic lesions in either the anterior thalamic nuclei or the mamillary bodies were compared with those of fornix lesions on a test of spatial working memory. All three lesions impaired acquisition of a forced alternation task in a T-maze, but the disruptive effects of the mamillary body lesions were significantly less than those following either fornix or anterior thalamic damage. When the alternation task was changed, so as to increase proactive interference, the impairment associated with mamillary body damage became more evident and was now equal in severity to that in the animals with anterior thalamic lesions. The fornix lesion group were the most impaired. In contrast, all three groups performed normally on a test of object recognition. The results add weight to the view that hippocampal--anterior thalamic connections are critical for normal spatial memory and that the relative contribution of the mamillary bodies is task dependent.
在空间工作记忆测试中，将丘脑前核或乳头体的细胞毒性损伤的影响与穹窿损伤的影响进行了比较。所有这三种损伤均损害了T迷宫中强迫交替任务的习得，但乳头体损伤的破坏作用明显小于穹窿或丘脑前损伤后的破坏作用。当改变交替任务以增加前摄干扰时，与乳头体损伤相关的损害变得更加明显，并且现在其严重程度与丘脑前损伤动物的损害程度相当。穹窿损伤组受损最严重。相比之下，所有三组在物体识别测试中表现正常。这些结果进一步支持了以下观点：海马体与丘脑前核的连接对于正常的空间记忆至关重要，并且乳头体的相对作用取决于任务。
