货物控制内吞作用。

Cargo takes control of endocytosis.

作者信息

Haucke Volker

机构信息

Institute of Chemistry and Biochemistry, Laboratory of Membrane Biochemistry, Freie Universität Berlin, Takustrasse 6, 14195 Berlin, Germany.

出版信息

Cell. 2006 Oct 6;127(1):35-7. doi: 10.1016/j.cell.2006.09.012.

DOI:10.1016/j.cell.2006.09.012

PMID:17018271

Abstract

Clathrin-mediated endocytosis is a major route for diverse cargo to enter the cellular endocytic pathway. New findings by Puthenveedu and von Zastrow (2006) suggest that certain cargo proteins, such as G protein coupled receptors that bind to PDZ domains, regulate their own targeting to a subset of clathrin-coated pits. Thus, cargo proteins may cause functional specialization of vesicle trafficking within the early endocytic pathway.

摘要

网格蛋白介导的内吞作用是多种货物进入细胞内吞途径的主要途径。Puthenveedu和von Zastrow（2006年）的新发现表明，某些货物蛋白，如与PDZ结构域结合的G蛋白偶联受体，会调节自身靶向至网格蛋白包被小窝的一个子集。因此，货物蛋白可能导致早期内吞途径中囊泡运输的功能特化。