School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Trends Cell Biol. 2010 Feb;20(2):71-8. doi: 10.1016/j.tcb.2009.11.006. Epub 2010 Jan 12.
Polarised vesicle trafficking has been suggested to regulate cell migration. Understanding how this takes place has been complicated by the use of disparate assays and cellular models. Although polarised trafficking does occur in cell motility it is not clear which pathways are involved. We propose a model for migrating cells where caveolar endocytosis occurs at the rear of the adherent surface, whereas clathrin-mediated endocytosis takes place in the middle-to-front region of the cell. We also suggest there is evidence to support polarised recycling of internalised cargo to the leading edge of migrating cells. Further research is required to confirm our hypothesis and a systematic evaluation of multiple pathways within individual systems and across different models is needed.
极化囊泡运输被认为可以调节细胞迁移。由于使用了不同的测定方法和细胞模型，因此了解这种情况变得复杂。尽管极化运输确实发生在细胞运动中，但尚不清楚涉及哪些途径。我们提出了一种用于迁移细胞的模型，其中囊泡内吞作用发生在附着表面的后部，而网格蛋白介导的内吞作用发生在细胞的中部到前部。我们还提出有证据表明，内化的货物被极化地再循环到迁移细胞的前沿。需要进一步的研究来证实我们的假设，并且需要对单个系统内和不同模型之间的多个途径进行系统评估。
