Carpenter Thomas O, DeLucia Maria C, Zhang Jane Hongyuan, Bejnerowicz Gina, Tartamella Lisa, Dziura James, Petersen Kitt Falk, Befroy Douglas, Cohen Dorothy
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8064, USA.
J Clin Endocrinol Metab. 2006 Dec;91(12):4866-72. doi: 10.1210/jc.2006-1391. Epub 2006 Oct 3.
The role of magnesium (Mg) as a determinant of bone mass has not been extensively explored. Limited studies suggest that dietary Mg intake and bone mineral density are correlated in adults, but no data from interventional studies in children and adolescents are available.
We sought to determine whether Mg supplementation in periadolescent girls enhances accrual of bone mass.
We carried out a prospective, placebo-controlled, randomized, one-year double-blind trial of Mg supplementation.
The study was conducted in the Clinical Research Centers at Yale University School of Medicine.
Healthy 8- to 14-yr-old Caucasian girls were recruited from community pediatricians' offices. Dietary diaries from over 120 volunteers were analyzed, and those with dietary Mg intake of less than 220 mg/d were invited to participate in the intervention.
Magnesium (300 mg elemental Mg per day in two divided doses) or placebo was given orally for 12 months.
The primary outcome measure was interval change in bone mineral content (BMC) of the total hip, femoral neck, Ward's area, and lumbar spine (L1-L4) after 12 months of Mg supplementation.
Significantly increased accrual (P = 0.05) in integrated hip BMC occurred in the Mg-supplemented vs. placebo group. Trends for a positive Mg effect were evident in the pre- and early puberty and in mid-late puberty. Lumbar spinal BMC accrual was slightly (but not significantly) greater in the Mg-treated group. Compliance was excellent; 73% of capsules were ingested as inferred by pill counts. Serum mineral levels, calciotropic hormones, and bone markers were similar between groups.
Oral Mg oxide capsules are safe and well tolerated. A positive effect of Mg supplementation on integrated hip BMC was evident in this small cohort.
镁（Mg）作为骨量决定因素的作用尚未得到广泛研究。有限的研究表明，成年人的膳食镁摄入量与骨矿物质密度相关，但尚无儿童和青少年干预研究的数据。
我们试图确定青春期前后女孩补充镁是否能增加骨量积累。
我们进行了一项关于补充镁的前瞻性、安慰剂对照、随机、为期一年的双盲试验。
该研究在耶鲁大学医学院临床研究中心进行。
从社区儿科医生办公室招募健康的8至14岁白种女孩。分析了120多名志愿者的饮食日记，邀请那些膳食镁摄入量低于220毫克/天的人参与干预。
口服镁（每天300毫克元素镁，分两次服用）或安慰剂，持续12个月。
主要观察指标是补充镁12个月后全髋、股骨颈、沃德氏区和腰椎（L1-L4）骨矿物质含量（BMC）的间隔变化。
与安慰剂组相比，补充镁组的全髋BMC累积显著增加（P = 0.05）。在青春期前和青春期早期以及青春期中后期，镁的积极作用趋势明显。镁治疗组的腰椎BMC累积略高（但不显著）。依从性良好；根据药丸计数推断，73%的胶囊被服用。两组之间的血清矿物质水平、促钙激素和骨标志物相似。
口服氧化镁胶囊安全且耐受性良好。在这个小队列中，补充镁对全髋BMC有明显的积极作用。
