Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Department of Physical Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
Biol Trace Elem Res. 2021 Jul;199(7):2523-2534. doi: 10.1007/s12011-020-02387-2. Epub 2020 Sep 21.
This study aimed to investigate the effects of vitamin D and magnesium co-supplementation on muscle strength and function, body composition, and inflammation in vitamin D-deficient middle-aged women. In this study, 83 healthy middle-aged women (40-55 years) with vitamin D deficiency were randomly assigned into two groups: (1) intervention: receiving a 50,000-IU vitamin D soft gel (weekly) plus a 250-mg magnesium tablet (daily); (2) control: receiving a vitamin D placebo (weekly) plus a magnesium placebo (daily), for 8 weeks. Before and after the intervention, anthropometric indices, muscle strength, muscle function, and some inflammatory markers were measured. After 8 weeks of supplementation, significant difference was observed in handgrip strength and time for Time Get Up and Go (TGUG) test between the intervention and placebo groups (P < 0.05). Regarding percentage of fat mass (FM%) and fat free mass (FFM%), and knee extension strength, there was no significant difference between the two groups at the end of intervention (P > .05). Serum 25(OH)-D levels increased significantly (P < 0.001) and its change was significantly different between the two groups, at the end of the intervention (P < 0.001). Serum level of hs-CRP decreased significantly in the intervention group compared to baseline (P < 0.001), and the change in hs-CRP was significant between the two groups at the end of the intervention (P < 0.01). Furthermore, serum level of TNF-α declined significantly in the intervention group compared to baseline (P < 0.001) but, no significant differences were seen between the two groups in regard of serum levels of TNF-α and IL-6 after the intervention (P > 0.05). Our findings show that vitamin D and magnesium co-supplementation, for 8 weeks, in healthy middle-aged women with vitamin D deficiency have beneficial impacts on muscle strength, muscle function, and probably inflammation.
本研究旨在探讨维生素 D 和镁联合补充对维生素 D 缺乏的中年女性肌肉力量和功能、身体成分和炎症的影响。在这项研究中，83 名健康的中年维生素 D 缺乏女性（40-55 岁）被随机分为两组：（1）干预组：每周服用 50000IU 维生素 D 软凝胶（每周一次）和每日服用 250mg 镁片；（2）对照组：每周服用维生素 D 安慰剂（每周一次）和每日服用镁安慰剂（每日一次），共 8 周。在干预前后，测量了人体测量指标、肌肉力量、肌肉功能和一些炎症标志物。补充 8 周后，干预组和安慰剂组的握力和起身时间（TGUG）测试时间有显著差异（P<0.05）。在干预结束时，两组间脂肪百分比（FM%）和无脂肪质量（FFM%）以及膝关节伸展力量没有显著差异（P>0.05）。血清 25（OH）-D 水平显著升高（P<0.001），且干预结束时两组间的变化有显著差异（P<0.001）。与基线相比，干预组血清 hs-CRP 水平显著降低（P<0.001），且干预结束时两组间 hs-CRP 的变化有显著差异（P<0.01）。此外，与基线相比，干预组血清 TNF-α水平显著降低（P<0.001），但干预后两组间 TNF-α和 IL-6 血清水平无显著差异（P>0.05）。我们的研究结果表明，维生素 D 和镁联合补充 8 周，对维生素 D 缺乏的中年健康女性的肌肉力量、肌肉功能和炎症可能有有益的影响。
