Bjarnsholt Thomas, Givskov Michael
Center for Biomedical Microbiology, BioCentrum-DTU Technical University of Denmark, Bldg 301, 2800, Lyngby, Denmark.
Anal Bioanal Chem. 2007 Jan;387(2):409-14. doi: 10.1007/s00216-006-0774-x. Epub 2006 Sep 26.
Recent decades have revealed that many bacterial species are capable of communicating with each other, and this observation has been largely responsible for a paradigm shift in microbiology. Whereas it was previously believed that bacteria lived as individual cells, it is now acknowledged that bacteria preferentially live in communities in the form of primitive organisms in which the behavior of individual cells is coordinated by cell-cell communication, known as quorum sensing (QS). Bacteria use QS for regulation of the processes involved in their interaction with each other, their environment, and, particularly, higher organisms We have focused on Pseudomonas aeruginosa, an opportunistic pathogen producing more than 30 QS-regulated virulence factors. P. aeruginosa causes several types of nosocomial infection, and lung infection in cystic fibrosis (CF) patients. We review the role of QS in the protective mechanisms of P. aeruginosa and show how disruption of the QS can be used as an approach to control this cunning aggressor.
近几十年来发现，许多细菌物种能够相互交流，这一观察结果在很大程度上促成了微生物学的范式转变。以前人们认为细菌以单个细胞的形式存在，而现在人们认识到细菌更喜欢以原始生物的形式生活在群落中，在这种群落中，单个细胞的行为通过细胞间通讯（称为群体感应，QS）来协调。细菌利用群体感应来调节它们彼此之间、与环境以及特别是与高等生物相互作用所涉及的过程。我们聚焦于铜绿假单胞菌，这是一种产生30多种受群体感应调节的毒力因子的机会致病菌。铜绿假单胞菌会引发几种类型的医院感染以及囊性纤维化（CF）患者的肺部感染。我们综述了群体感应在铜绿假单胞菌保护机制中的作用，并展示了如何通过破坏群体感应来控制这种狡猾的侵略者。
