Morgello S, Holzer C E, Ryan E, Young C, Naseer M, Castellon S A, Frol A B, Atkinson J Hampton, Gelman B B, Grant I, Singer E J
Mount Sinai School of Medicine, New York, NY10029, USA.
Int J Methods Psychiatr Res. 2006;15(3):131-8. doi: 10.1002/mpr.189.
The interrater reliability of the Psychiatric Research Interview for Substance and Mental Disorders (PRISM) was assessed in a multicentre study. Four sites of the National NeuroAIDS Tissue Consortium performed blinded reratings of audiotaped PRISM interviews of 63 HIV-infected patients. Diagnostic modules for substance-use disorders and major depression were evaluated. Seventy-six per cent of the patient sample displayed one or more substance-use disorder diagnoses and 54% had major depression. Kappa coefficients for lifetime histories of substance abuse or dependence (cocaine, opiates, alcohol, cannabis, sedative, stimulant, hallucinogen) and major depression ranged from 0.66 to 1.00. Overall the PRISM was reliable in assessing both past and current disorders except for current cannabis disorders when patients had concomitant cannabinoid prescriptions for medical therapy. The reliability of substance-induced depression was poor to fair although there was a low prevalence of this diagnosis in our group. We conclude that the PRISM yields reliable diagnoses in a multicentre study of substance-experienced, HIV-infected individuals.
在一项多中心研究中评估了物质与精神障碍的精神病学研究访谈（PRISM）的评分者间信度。国家神经艾滋病组织联盟的四个地点对63名感染HIV患者的PRISM访谈录音进行了盲法重新评分。对物质使用障碍和重度抑郁症的诊断模块进行了评估。76%的患者样本显示有一种或多种物质使用障碍诊断，54%患有重度抑郁症。物质滥用或依赖（可卡因、阿片类药物、酒精、大麻、镇静剂、兴奋剂、致幻剂）和重度抑郁症的终生病史的kappa系数范围为0.66至1.00。总体而言，PRISM在评估过去和当前的疾病方面是可靠的，但当患者有用于医学治疗的大麻素处方时，对于当前大麻疾病的评估除外。物质所致抑郁症的信度较差至尚可，尽管在我们的研究组中这种诊断的患病率较低。我们得出结论，在一项针对有物质使用经历的感染HIV个体的多中心研究中，PRISM能得出可靠的诊断结果。
