Berney Alexandre, Preisig Martin, Matthey Marie-Louise, Ferrero François, Fenton Brenda T
University Department of Adult Psychiatry, Hôpital de Cery, CH-1008 Prilly-Lausanne, Switzerland.
Drug Alcohol Depend. 2002 Jan 1;65(2):149-58. doi: 10.1016/s0376-8716(01)00156-9.
The semi-structured diagnostic interview for genetic studies (DIGS) was developed to assess major mood and psychotic disorders and their spectrum manifestations in genetic studies. Our research group developed a French version of the DIGS and tested its inter-rater and test-retest reliability in psychiatric patients. In this article, we present estimates of the reliability of substance use and antisocial personality disorders. High kappa coefficients for inter-rater reliability were found for drug and alcohol as well as antisocial personality diagnoses and slightly lower kappas for test-retest reliability. Combined with evidence of the reliability of major mood and psychotic disorders, these findings support the suitability of the DIGS for studies of familial aggregation and comorbidity of psychiatric disorders including substance use and antisocial personality disorders.
用于基因研究的半结构化诊断访谈（DIGS）旨在评估基因研究中的主要情绪和精神障碍及其谱系表现。我们的研究小组开发了DIGS的法语版本，并在精神病患者中测试了其评分者间信度和重测信度。在本文中，我们给出了物质使用障碍和反社会人格障碍的信度估计。药物和酒精以及反社会人格诊断的评分者间信度的kappa系数较高，重测信度的kappa系数略低。结合主要情绪和精神障碍信度的证据，这些发现支持DIGS适用于包括物质使用障碍和反社会人格障碍在内的精神障碍家族聚集性和共病性研究。
