Willkens R F, Nepom G T, Marks C R, Nettles J W, Nepom B S
Harborview Medical Center, Seattle, WA 98104.
Arthritis Rheum. 1991 Jan;34(1):43-7. doi: 10.1002/art.1780340107.
Rheumatoid arthritis (RA) is prevalent in Yakima Indians, a Native American tribe. HLA-DR4, the HLA specificity commonly associated with RA in Caucasians, is rare among the Yakima. Using a specific oligonucleotide probe that recognizes DR4 nucleotide sequences associated with RA, a rare HLA-Dw16 gene was identified in 83% of Yakima patients with RA and in 60% of Yakima control subjects. This shared sequence encodes a discrete class II epitope that is highly correlated with RA in both DR4 positive and DR4 negative individuals.
类风湿性关节炎（RA）在美洲原住民部落雅基马印第安人中很普遍。HLA - DR4是白种人中通常与RA相关的HLA特异性，在雅基马人中很少见。使用一种识别与RA相关的DR4核苷酸序列的特异性寡核苷酸探针，在83%的雅基马RA患者和60%的雅基马对照受试者中鉴定出一种罕见的HLA - Dw16基因。这种共享序列编码一个离散的II类表位，在DR4阳性和DR4阴性个体中都与RA高度相关。
