Yeo Ronald A, Phillips John P, Jung Rex E, Brown April J, Campbell Richard C, Brooks William M
Department of Psychology, University of New Mexico, Albuquerque, New Mexico 87131, USA.
J Neurotrauma. 2006 Oct;23(10):1427-35. doi: 10.1089/neu.2006.23.1427.
Proton magnetic resonance spectroscopy (1H-MRS) and neuropsychological assessment were utilized in a longitudinal investigation of traumatic brain injury (TBI) in children. A spectroscopic imaging protocol was implemented, and neurometabolite ratios of NAA/Cre and Cho/Cre were calculated for anterior and posterior halves of a supraventricular slab of brain tissue. NAA/Cre was reduced and Cho/Cre increased in TBI patients as compared to controls, for both brain regions. Each ratio predicted aspects of neuropsychological performance, though the specific relationships varied somewhat by region and function. Anterior NAA/Cre increased and anterior Cho/Cre decreased from 3 to 21 weeks post-injury, suggesting neurometabolic recovery.
质子磁共振波谱（1H-MRS）和神经心理学评估被用于一项针对儿童创伤性脑损伤（TBI）的纵向研究。实施了一种波谱成像方案，并计算了脑组织室上层面板前半部分和后半部分的NAA/Cre和Cho/Cre神经代谢物比率。与对照组相比，TBI患者两个脑区的NAA/Cre均降低，Cho/Cre均升高。每个比率都能预测神经心理学表现的某些方面，尽管具体关系因区域和功能而有所不同。受伤后3至21周，前半部分的NAA/Cre升高，前半部分的Cho/Cre降低，提示神经代谢恢复。
