数量分泌：原核生物中的蛋白质运输
Secretion by numbers: Protein traffic in prokaryotes.
作者信息
Economou Anastasias, Christie Peter J, Fernandez Rachel C, Palmer Tracy, Plano Greg V, Pugsley Anthony P
机构信息
Institute of Molecular Biology and Biotechnology, F O R T H and University of Crete, PO Box 1527, GR-711 10 Iraklio, Crete, Greece.
出版信息
Mol Microbiol. 2006 Oct;62(2):308-19. doi: 10.1111/j.1365-2958.2006.05377.x.
Abstract
Almost all aspects of protein traffic in bacteria were covered at the ASM-FEMS meeting on the topic in Iraklio, Crete in May 2006. The studies presented ranged from mechanistic analysis of specific events leading proteins to their final destinations to the physiological roles of the targeted proteins. Among the highlights from the meeting that are reviewed here are the molecular dynamics of SecA protein, membrane protein insertion, type III secretion needles and chaperones, type IV secretion, the two partner and autosecretion systems, the 'secretion competent state', and the recently discovered type VI secretion system.
摘要
2006年5月在克里特岛伊拉克利翁举行的美国微生物学会-欧洲微生物学会联合会会议上，几乎涵盖了细菌中蛋白质运输的各个方面。会上展示的研究范围从导致蛋白质到达其最终目的地的特定事件的机制分析，到目标蛋白质的生理作用。本文回顾的会议亮点包括SecA蛋白的分子动力学、膜蛋白插入、III型分泌针和伴侣蛋白、IV型分泌、双伴侣和自分泌系统、“分泌能力状态”以及最近发现的VI型分泌系统。
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