Forgue M F, Pinelli E, Beraud M, Souqual M C, Pipy B
INSERM U87, Université Paul Sabatier, Toulouse, France.
Food Addit Contam. 1990;7 Suppl 1:S97-9. doi: 10.1080/02652039009373856.
The influence of gamma-hexachlorocyclohexane (gamma-HCCH) on arachidonic acid (AA) metabolism and oxygen metabolite production was investigated on mouse peritoneal macrophages gamma-HCCH stimulated 6KPGF1 alpha, PGE2, LTC4, LTB4 and HETEs production and increased the luminol-dependent chemiluminescence (CL). Lindane acted synergistically with phorbol ester on prostaglandins-leukotrienes (PGs-LTs) and CL production. Similar stimulation of CL and PGs-LTs production was found after challenge by the calcium ionophore A23187. The implication of calcium mobilization in lindane effects was proposed.
研究了γ-六氯环己烷（γ-HCCH）对小鼠腹腔巨噬细胞花生四烯酸（AA）代谢和氧代谢产物生成的影响。γ-HCCH刺激了6-酮-前列腺素F1α、前列腺素E2、白三烯C4、白三烯B4和羟二十碳四烯酸（HETEs）的生成，并增加了鲁米诺依赖性化学发光（CL）。林丹与佛波酯在前列腺素-白三烯（PGs-LTs）和CL生成方面具有协同作用。在用钙离子载体A23187刺激后，发现对CL和PGs-LTs生成有类似的刺激作用。有人提出钙离子动员与林丹的作用有关。
