Catta-Preta Mariana, Oliveira Daniel Alves, Mandarim-de-Lacerda Carlos Alberto, Aguila Marcia Barbosa
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Brazil.
Life Sci. 2006 Dec 23;80(3):219-29. doi: 10.1016/j.lfs.2006.09.004. Epub 2006 Sep 16.
We investigated the effect of fish oil (FO) treatment on cardiorenal structure of adult offspring from low-protein pregnancies. Three month old offspring were assigned to eight groups (four male groups and four female groups, n=8 each) (NP=normal-protein diet, LP=low-protein diet): NP, LP, NP plus FO, and LP plus FO. Left ventricle and kidney were analyzed with light microscopy and stereology. The both sexes of LP offspring showed 30% lower birth weights than the respective NP offspring and high blood pressure (BP) levels in adulthood which was efficiently reduced by FO treatment. In the heart, FO treated the cardiomyocyte hypertrophy, the vascularization impairment, and decreased the cardiomyocyte loss usually observed in adult LP offspring. In the kidney, FO treated, in the male, the imbalance of the cortex-to-medulla ratio observed in both sexes of LP offspring, and reduced the glomeruli loss in the LP offspring. The positive correlation between the number of cardiomyocyte nuclei later in life and the body mass (BM) at birth was significant only in both sexes of LP offspring and this correlation disappeared in LP plus fish oil offspring. The positive correlation between the number of glomeruli later in life and the BM at birth was significant in NP male offspring and in both sexes of LP offspring. In conclusion, FO supplement, which is a rich source of n-3 fatty acids (DHA and EPA), has beneficial effects on BP control and cardiac and renal adverse remodeling usually seen in offspring of the LP pregnancies.
我们研究了鱼油（FO）治疗对低蛋白妊娠成年后代心脏和肾脏结构的影响。将3个月大的后代分为八组（四组雄性和四组雌性，每组n = 8）（NP = 正常蛋白饮食，LP = 低蛋白饮食）：NP、LP、NP加FO和LP加FO。通过光学显微镜和体视学分析左心室和肾脏。LP后代的两性出生体重均比各自的NP后代低30%，且成年后血压水平较高，而FO治疗可有效降低血压。在心脏方面，FO治疗了成年LP后代通常出现的心肌细胞肥大、血管生成受损，并减少了心肌细胞损失。在肾脏方面，FO治疗在雄性中改善了LP后代两性中观察到的皮质与髓质比例失衡，并减少了LP后代的肾小球损失。仅在LP后代的两性中，生命后期心肌细胞核数量与出生时体重（BM）之间的正相关显著，而在LP加鱼油后代中这种相关性消失。生命后期肾小球数量与出生时BM之间的正相关在NP雄性后代和LP后代的两性中显著。总之，富含n - 3脂肪酸（DHA和EPA）的FO补充剂对血压控制以及LP妊娠后代中常见的心脏和肾脏不良重塑具有有益作用。
