Bezerra Daniele Gonçalves, Lacerda Andrade Lívia Marinho, Pinto da Cruz Fernanda Ornellas, Mandarim-de-Lacerda Carlos Alberto
Laboratory of Morphometry and Cardiovascular Morphology, Biomedical Centre, Institute of Biology, State University of Rio de Janeiro, Av 28 de Setembro, 87 (fds)-20551-030 Rio de Janeiro, RJ, Brasil.
J Card Fail. 2008 Mar;14(2):151-60. doi: 10.1016/j.cardfail.2007.10.015.
Statins are cholesterol-lowering drugs that have been proved to prevent cardiac events. Their direct effects on cardiac remodeling, when administered in programmed protein restricted animals, still are unknown.
Wistar male 6-month-old offspring from dams fed normal protein (NP, 19% of protein) or low-protein (LP, 5% of protein) during pregnancy and first 10 days after birth were studied. After weaning, male pups were allocated to untreated or treated groups with atorvastatin (low and high doses, 5 or 30 mg.kg.day) in two different periods (from 21 days old to 3 months old and from 3 to 6 months old). The blood pressure (BP) was 30% greater in untreated LP offspring than in treated offspring (from 165 +/- 6 mm Hg to 127 +/- 3 mm Hg, P < .01). After 1 month of treatment, only untreated LP offspring continued with high BP. Compared with untreated LP offspring, atorvastatin reduced blood glucose (less 30%, P < .05) and cardiomyocyte size (less 24%, P < .05), whereas untreated LP offspring had greater interstitial fibrosis (plus 74%, P < .01), reduction of myocardial vascularization (less 25%, P < .01) and major reduction of cardiomyocyte number (less 38%, P < .01) than treated LP offspring.
Atorvastatin from 3 to 6 months olds in both low and high doses (but not from 0 to 3 months) has beneficial effects improving myocardial vascularization by diminishing fibrosis and cardiomyocyte loss.
他汀类药物是已被证明可预防心脏事件的降胆固醇药物。在蛋白质摄入受限的动物中给予他汀类药物时，其对心脏重塑的直接影响尚不清楚。
研究了孕期及出生后前10天喂食正常蛋白质（NP，蛋白质含量19%）或低蛋白质（LP，蛋白质含量5%）的母鼠所产的6月龄雄性Wistar后代。断奶后，雄性幼崽在两个不同时期（从21日龄至3月龄以及从3至6月龄）被分配至未治疗组或用阿托伐他汀治疗组（低剂量和高剂量，分别为5或30 mg·kg·天）。未治疗的LP后代的血压比治疗后代高30%（从165±6 mmHg降至127±3 mmHg，P<.01）。治疗1个月后，只有未治疗的LP后代持续保持高血压。与未治疗的LP后代相比，阿托伐他汀降低了血糖（降低30%，P<.05）和心肌细胞大小（降低24%，P<.05），而未治疗的LP后代比接受治疗的LP后代有更严重的间质纤维化（增加74%，P<.01）、心肌血管化减少（减少25%，P<.01）以及心肌细胞数量大幅减少（减少38%，P<.01）。
3至6月龄的幼崽无论使用低剂量还是高剂量的阿托伐他汀（但0至3月龄时无效）均有有益作用，可通过减少纤维化和心肌细胞丢失来改善心肌血管化。
