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丙型肝炎病毒（HCV）抗原抗体联合检测法并不能改善对隐匿性HCV感染血清学阴性个体的诊断。

Combined hepatitis C virus (HCV) antigen-antibody detection assay does not improve diagnosis for seronegative individuals with occult HCV infection.

作者信息

Quiroga Juan A, Castillo Inmaculada, Pardo Margarita, Rodríguez-Iñigo Elena, Carreño Vicente

机构信息

Fundación para el Estudio de las Hepatitis Virales, Guzmán el Bueno 72, 28015 Madrid, Spain.

出版信息

J Clin Microbiol. 2006 Dec;44(12):4559-60. doi: 10.1128/JCM.01440-06. Epub 2006 Oct 4.

DOI:10.1128/JCM.01440-06
PMID:17021056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698377/
Abstract

A combined hepatitis C virus (HCV) antigen-antibody assay was evaluated for 115 seronegative individuals with occult HCV infection. The assay was reactive in one patient and negative to weakly reactive in three others (all four gave indeterminate results by supplemental assay) but failed to detect HCV in the remaining patients. Despite increased sensitivity the combined assay does not improve serodiagnosis of occult HCV infection.

摘要

对115例隐匿性丙型肝炎病毒（HCV）感染的血清学阴性个体进行了丙型肝炎病毒抗原 - 抗体联合检测。该检测在1例患者中呈阳性反应，在另外3例患者中呈阴性至弱阳性反应（通过补充检测，这4例结果均不确定），但在其余患者中未检测到HCV。尽管联合检测的敏感性有所提高，但它并未改善隐匿性HCV感染的血清学诊断。

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本文引用的文献

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Early detection of hepatitis C virus infection by use of a new combined antigen-antibody detection assay: potential use for high-risk individuals.使用新型联合抗原-抗体检测法早期检测丙型肝炎病毒感染：对高危人群的潜在用途。
J Clin Microbiol. 2006 Apr;44(4):1561-3. doi: 10.1128/JCM.44.4.1561-1563.2006.
2
Is an assay for simultaneous detection of hepatitis C virus core antigen and antibody a valuable alternative to nucleic acid testing?丙型肝炎病毒核心抗原和抗体同时检测的检测方法是否是核酸检测的一种有价值的替代方法？
Transfusion. 2005 Dec;45(12):1965-72. doi: 10.1111/j.1537-2995.2005.00648.x.
3
Combination hepatitis C virus antigen and antibody immunoassay as a new tool for early diagnosis of infection.丙型肝炎病毒抗原和抗体联合免疫测定作为感染早期诊断的新工具。
J Viral Hepat. 2006 Jan;13(1):5-10. doi: 10.1111/j.1365-2893.2005.00646.x.
4
Simultaneous detection of hepatitis C virus (HCV) core antigen and anti-HCV antibodies improves the early detection of HCV infection.丙型肝炎病毒（HCV）核心抗原与抗-HCV抗体的同时检测可提高HCV感染的早期检测率。
J Clin Microbiol. 2005 Aug;43(8):3877-83. doi: 10.1128/JCM.43.8.3877-3883.2005.
5
HCV-indeterminate blood donors or occult HCV infection?丙型肝炎病毒检测结果不确定的献血者还是隐匿性丙型肝炎病毒感染？
Lancet. 2005;365(9470):1540-1; author reply 1541. doi: 10.1016/S0140-6736(05)66451-3.
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