Booke Michael, Westphal Martin
Department of Anesthesiology, Kliniken des Main-Taunus-Kreises GmbH, Bad Soden am Taunus, Germany.
Curr Opin Anaesthesiol. 2003 Apr;16(2):101-4. doi: 10.1097/00001503-200304000-00001.
For years, the field of sepsis research was extremely active; the net result, however, was rather disappointing. Sepsis is still a major problem in intensive care units worldwide. Frustratingly, sepsis is characterized by a high morbidity and mortality. Although multiple (animal) studies with promising results have been published, the clinical situation has changed only a little. However, the recent 2 or 3 years of sepsis research brought significant results that will have a significant impact on clinical routine.
In the last 2 years, three big randomized controlled clinical trials were published on treatment of sepsis, each leading to a significant improvement in outcome: administration of activated protein C, administration of low dose corticosteroids, and maintenance of strict normoglycemia.
A breakthrough in sepsis research was long awaited. Recent clinical studies demonstrated that an improvement in outcome can be achieved even with simple means. This review focuses on these new therapeutic concepts, hopefully helping to transfer scientific advantages into everyday clinical routine.
多年来，脓毒症研究领域极为活跃；然而，最终结果却相当令人失望。脓毒症仍是全球重症监护病房面临的一个主要问题。令人沮丧的是，脓毒症具有高发病率和高死亡率的特点。尽管已经发表了多项（动物）研究且结果颇具前景，但临床状况变化甚微。然而，最近两三年的脓毒症研究取得了重大成果，将对临床常规产生重大影响。
在过去两年中，发表了三项关于脓毒症治疗的大型随机对照临床试验，每项试验都使治疗结果得到了显著改善：应用活化蛋白C、应用低剂量皮质类固醇以及维持严格的血糖正常水平。
脓毒症研究的突破早已为人所期待。近期的临床研究表明，即使采用简单的方法也能实现治疗结果的改善。本综述聚焦于这些新的治疗理念，有望助力将科学优势转化为日常临床实践。
