Tsangalis D, Wilcox G, Shah N P, McGill A E J, Stojanovska L
Food Safety, Authenticity & Quality Unit, School of Molecular Sciences, Victoria University, Werribee, Victoria, Australia.
Eur J Clin Nutr. 2007 Mar;61(3):438-41. doi: 10.1038/sj.ejcn.1602530. Epub 2006 Oct 4.
To study the effects of consuming isoflavone aglycone-enriched soymilk fermented by bifidobacteria on urinary excretion of equol with respect to fermentation, daidzein dose, supplementation duration and background diet.
Double-blind crossover pilot study comprising three 14-day supplementation periods separated by a washout.
Victoria University, Melbourne, Australia.
Sixteen postmenopausal women.
SUBJECTS randomized into two groups consuming either fermented (FS) or non-fermented soymilk (NFS), ingested three daily dosages of daidzein via soymilk and collected pooled urine specimens. Daidzein and equol were quantified using high-performance liquid chromatography.
After 14-days supplementation six women (38%) excreted equol (>1 micromol equol/day), including four from the FS group, two of whom were classified as non-producers at day 4. Bifidobacteria ingestion, composition of daidzein and its glucosides, and carbohydrate intake appeared to influence equol formation among equol producers.
Pilot-study group mean urinary equol excretion results provided insufficient evidence (P>0.05) that FS consumption instigates equol production in women predetermined as non-producers.
研究饮用经双歧杆菌发酵的富含异黄酮苷元的豆浆对雌马酚尿排泄量的影响，涉及发酵、大豆苷元剂量、补充持续时间和基础饮食等因素。
双盲交叉试点研究，包括三个为期14天的补充期，期间有洗脱期。
澳大利亚墨尔本维多利亚大学。
16名绝经后女性。
将受试者随机分为两组，分别饮用发酵豆浆（FS）或未发酵豆浆（NFS），通过豆浆每日摄入三种剂量的大豆苷元，并收集合并尿液样本。使用高效液相色谱法定量大豆苷元和雌马酚。
补充14天后，6名女性（38%）排泄出雌马酚（>1微摩尔雌马酚/天），其中4名来自FS组，其中2名在第4天时被归类为非雌马酚生产者。摄入双歧杆菌、大豆苷元及其糖苷的组成以及碳水化合物摄入量似乎会影响雌马酚生产者中雌马酚的形成。
试点研究组雌马酚尿排泄量的平均结果提供的证据不足（P>0.05），表明饮用FS不会促使预先确定为非生产者的女性产生雌马酚。
