Keane Thomas E, Rosner Inger L, Wingo M Scott, McLeod David G
Rev Urol. 2006;8 Suppl 1(Suppl 1):S20-8.
The ability to label tissue-specific antibodies has long been of interest for improving detection and guidance for therapeutic applications. The most studied target for prostate cancer is the prostate-specific membrane antigen, which is upregulated in prostate cancer, hormone-refractive disease, and prostate cancer metastases. Investigations using radioimmunoscintigraphy with the radiolabeled 7E11 antibody capromab pendetide have significantly improved sensitivity for prostate cancer detection compared with standard cross-sectional imaging, based on tissue confirmation of pathologic results. Over the past 5 years, significantly greater image resolution from improved camera technology and the use of co-registration to fuse functional and anatomic (computerized tomography and magnetic resonance imaging) images have dramatically enhanced prostate cancer localization. Outcomes data from several sources have spurred a resurgence in interest in this imaging modality.
长期以来，标记组织特异性抗体的能力一直备受关注，这有助于改善检测效果并为治疗应用提供指导。前列腺癌研究最多的靶点是前列腺特异性膜抗原，它在前列腺癌、激素难治性疾病和前列腺癌转移中上调。与标准横断面成像相比，使用放射性标记的7E11抗体卡波单抗喷地肽进行放射免疫闪烁显像的研究显著提高了前列腺癌检测的灵敏度，这基于病理结果的组织确认。在过去5年中，改进的相机技术以及使用配准融合功能和解剖（计算机断层扫描和磁共振成像）图像所带来的显著更高的图像分辨率，极大地提高了前列腺癌的定位能力。来自多个来源的结果数据激发了人们对这种成像方式兴趣的复苏。
