Schwab Albrecht, Nechyporuk-Zloy Volodymyr, Fabian Anke, Stock Christian
Institut für Physiologie II, Universität Münster, Robert-Koch-Str. 27b, 48149, Münster, Germany.
Pflugers Arch. 2007 Jan;453(4):421-32. doi: 10.1007/s00424-006-0138-6. Epub 2006 Oct 5.
Cell migration is a process that plays an important role throughout the entire life span. It starts early on during embryogenesis and contributes to shaping our body. Migrating cells are involved in maintaining the integrity of our body, for instance, by defending it against invading pathogens. On the other side, migration of tumor cells may have lethal consequences when tumors spread metastatically. Thus, there is a strong interest in unraveling the cellular mechanisms underlying cell migration. The purpose of this review is to illustrate the functional importance of ion and water channels as part of the cellular migration machinery. Ion and water flow is required for optimal migration, and the inhibition or genetic ablation of channels leads to a marked impairment of migration. We briefly touch cytoskeletal mechanisms of migration as well as cell-matrix interactions. We then present some general principles by which channels can affect cell migration before we discuss each channel group separately.
细胞迁移是一个在整个生命周期中都发挥着重要作用的过程。它在胚胎发育早期就开始了，并有助于塑造我们的身体。迁移的细胞参与维持我们身体的完整性，例如通过抵御入侵的病原体来保护身体。另一方面，当肿瘤发生转移扩散时，肿瘤细胞的迁移可能会产生致命后果。因此，人们对揭示细胞迁移背后的细胞机制有着浓厚的兴趣。本综述的目的是阐明离子通道和水通道作为细胞迁移机制一部分的功能重要性。最佳迁移需要离子和水流，通道的抑制或基因敲除会导致迁移明显受损。我们简要介绍迁移的细胞骨架机制以及细胞与基质的相互作用。然后，在分别讨论每个通道组之前，我们提出一些通道影响细胞迁移的一般原则。
