Demontis Fabio, Habermann Bianca, Dahmann Christian
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany.
Dev Genes Evol. 2006 Nov;216(11):737-41. doi: 10.1007/s00427-006-0097-0. Epub 2006 Oct 5.
Cadherins are Ca(2+)-dependent cell adhesion molecules that play fundamental roles in animal development and homeostasis. A number of cadherins contain conserved binding sites for catenins in their cytoplasmic region that are important for the adhesive function of these cadherins by mediating their interaction to the cytoskeleton. However, most cadherins lack apparent binding sites for catenins and their cytoplasmic interacting partners are mostly unknown. In this paper, we show, using bioinformatics, that a number of insect and vertebrate cadherins lacking catenin-binding sites contain conserved consensus sequences for C-terminal PSD-95/Discs-large/ZO-1 (PDZ)-domain-binding sites. This suggests that PDZ-domain-containing proteins are common cytoplasmic interacting partners for cadherins lacking catenin-binding sites.
钙黏着蛋白是依赖钙离子的细胞黏附分子，在动物发育和体内平衡中发挥着重要作用。许多钙黏着蛋白在其细胞质区域含有与连环蛋白的保守结合位点，这些位点通过介导它们与细胞骨架的相互作用，对这些钙黏着蛋白的黏附功能很重要。然而，大多数钙黏着蛋白缺乏明显的连环蛋白结合位点，其细胞质相互作用伙伴大多未知。在本文中，我们通过生物信息学表明，一些缺乏连环蛋白结合位点的昆虫和脊椎动物钙黏着蛋白含有C端PSD-95/盘状大蛋白/ZO-1（PDZ）结构域结合位点的保守共有序列。这表明含PDZ结构域的蛋白质是缺乏连环蛋白结合位点的钙黏着蛋白常见的细胞质相互作用伙伴。
