Liu S
Department of Neurobiology, Fourth Military Medical University, Xian, People's Republic of China.
Eur J Neurosci. 1995 Aug 1;7(8):1664-73. doi: 10.1111/j.1460-9568.1995.tb00688.x.
The anterior pituitary has recently been confirmed to be innervated by substance P-immunoreactive nerve fibres in the monkey and human. The present study investigated the morphology of the nerve fibres and their relationship with anterior pituitary gland cells in the macaque by means of immunoelectron microscopy. Many substance P-immunoreactive and unlabelled nerve fibres were distributed among the gland cells or formed nerve fibre bundles. These nerve fibres were unmyelinated and varicose, and contained a great many clear and/or large dense-cored vesicles. Substance P-immunoreactive cells were seen in the pars distalis of the anterior pituitary. Direct contacts between these nerve fibres and every cell type of the gland could be ascertained, including substance P-immunoreactive cells. Synaptoid contacts were seen among the substance P-immunoreactive varicosities and somatotropes, opiocortico-melanotropes and folliculostellate cells. Typical synapses were identified in somatotropes and opiocortico-melanotropes.
最近已证实，在猴子和人类中，垂体前叶受P物质免疫反应性神经纤维支配。本研究通过免疫电子显微镜研究了猕猴中神经纤维的形态及其与垂体前叶腺细胞的关系。许多P物质免疫反应性和未标记的神经纤维分布在腺细胞之间或形成神经纤维束。这些神经纤维无髓且有曲张，含有大量清亮和/或大的致密核心小泡。在垂体前叶远侧部可见P物质免疫反应性细胞。可以确定这些神经纤维与腺的每种细胞类型之间的直接接触，包括P物质免疫反应性细胞。在P物质免疫反应性曲张与生长激素细胞、促肾上腺皮质激素-促黑素细胞和滤泡星状细胞之间可见类突触接触。在生长激素细胞和促肾上腺皮质激素-促黑素细胞中鉴定出典型突触。
