δ-环糊精作为通过电迁移方法进行对映体分离的新型手性探针。
Delta-cyclodextrin as novel chiral probe for enantiomeric separation by electromigration methods.
作者信息
Wistuba Dorothee, Bogdanski Anja, Larsen Kim L, Schurig Volker
机构信息
Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany.
出版信息
Electrophoresis. 2006 Nov;27(21):4359-63. doi: 10.1002/elps.200600284.
Native delta-CD has been employed as chiral selector in CE and MEKC. To investigate the potential of the enantiodiscriminating properties of delta-CD, negatively charged 5-dimethylamino-1-naphthalene-sulfonyl (dansyl)-, 2,4-dinitrophenyl (DNP)- and FMOC-derivatives of several amino acids, 1,1'-binaphthyl-2,2'-diylhydrogenphosphate, flavanones and three positively charged drugs have been selected as testing samples. Enantioresolution factors up to 4.82 have been observed. The results were compared with those achieved by the conventional running buffer additives alpha-, beta- and gamma-CDs. For several examples a steady increase of enantioresolution with increasing degree of oligomerization has been detected.
天然δ-环糊精已被用作毛细管电泳（CE）和胶束电动毛细管色谱（MEKC）中的手性选择剂。为了研究δ-环糊精对映体识别特性的潜力，已选择了几种氨基酸的带负电荷的5-二甲基氨基-1-萘磺酰基（丹磺酰基）、2,4-二硝基苯基（DNP）和芴甲氧羰基（FMOC）衍生物、1,1'-联萘-2,2'-二磷酸氢酯、黄烷酮以及三种带正电荷的药物作为测试样品。已观察到对映体拆分因子高达4.82。将结果与通过传统运行缓冲添加剂α-、β-和γ-环糊精获得的结果进行了比较。对于几个例子，已检测到随着低聚程度的增加对映体拆分稳步增加。
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