丙型慢性肝炎患者在干扰素治疗期间外周血单个核细胞产生肿瘤坏死因子α和白细胞介素1β
Production of tumor necrosis factor alpha and interleukin 1 beta by peripheral blood mononuclear cells from chronic hepatitis type C patients during interferon therapy.
作者信息
Ueno Y, Suzuki H, Kobayashi K, Miura M, Toyota T
机构信息
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
出版信息
Tohoku J Exp Med. 1990 Jun;161(2):157-8. doi: 10.1620/tjem.161.157.
To elucidate the role of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) in chronic hepatitis type C (CH(C], TNF alpha and IL-1 beta released from peripheral blood mononuclear cells were measured in 6 CH(C) patients before and during interferon therapy. During the therapy, TNF-alpha levels were significantly high in two patients whose serum ALT levels turned normal, while IL-1 beta levels did not show significant change. These results suggest that TNF-alpha takes part in improvement of CH(C).
为阐明肿瘤坏死因子α（TNF-α）和白细胞介素1β（IL-1β）在丙型慢性肝炎（CHC）中的作用，对6例CHC患者在干扰素治疗前及治疗期间外周血单个核细胞释放的TNF-α和IL-1β进行了检测。治疗期间，血清ALT水平恢复正常的2例患者TNF-α水平显著升高，而IL-1β水平无明显变化。这些结果提示TNF-α参与了CHC的病情改善。
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