Szyrwińska Katarzyna, Lulek Janina
Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
Chemosphere. 2007 Jan;66(10):1895-903. doi: 10.1016/j.chemosphere.2006.08.010. Epub 2006 Oct 4.
The aim of our study was to obtain the data on the exposure of breast-fed infants to polychlorinated biphenyls (PCBs) and selected organochlorine pesticides (OCPs) in the Wielkopolska province (Poland). The levels of indicator PCBs, and selected OCPs, including two DDT metabolites (HCB, p,p'-DDT, p,p'-DDD, p,p'-DDE and alpha,beta,gamma-HCH) were determined in 27 human milk samples, collected in 2000-2001, according to WHO protocol. Estimated daily intakes (EDIs) of all analytes were calculated. Our results were compared with those obtained by an analysis of human milk samples from other European and non-European countries, collected in the same period time. We have stated that median exposure of Wielkopolska first breast-fed infants to OCPs is comparable (EDI(HCB) = 0.086 microg/kgbw/day; EDI(beta-HCH)=0.063 microg/kgbw/day) or higher (EDI(p,p'-DDE) = 3.495 microg/kgbw/day) than in other European countries, while exposure to PCBs (EDI(Sigma7PCB) = 0.364 microg/kgbw/day) is situated at the low end of the intake of these xenobiotics by breast-fed infants from different regions of Europe.
我们研究的目的是获取波兰大波兰省母乳喂养婴儿接触多氯联苯（PCBs）和特定有机氯农药（OCPs）的数据。根据世界卫生组织的方案，对2000 - 2001年采集的27份母乳样本中指示性多氯联苯以及特定有机氯农药的含量进行了测定，这些农药包括两种滴滴涕代谢物（六氯苯、p,p'-滴滴涕、p,p'-滴滴滴、p,p'-滴滴伊以及α,β,γ-六氯环己烷）。计算了所有分析物的估计每日摄入量（EDIs）。我们将结果与同期对来自其他欧洲和非欧洲国家的母乳样本分析所得结果进行了比较。我们指出，大波兰省首次母乳喂养婴儿对有机氯农药的中位数暴露量与其他欧洲国家相当（六氯苯的估计每日摄入量 = 0.086微克/千克体重/天；β-六氯环己烷的估计每日摄入量 = 0.063微克/千克体重/天）或更高（p,p'-滴滴伊的估计每日摄入量 = 3.495微克/千克体重/天），而对多氯联苯的暴露量（七氯联苯总和的估计每日摄入量 = 0.364微克/千克体重/天）处于欧洲不同地区母乳喂养婴儿摄入这些外源性物质的低端水平。
