Jaraczewska Kamila, Lulek Janina, Covaci Adrian, Voorspoels Stefan, Kaluba-Skotarczak Agnieszka, Drews Krzysztof, Schepens Paul
Department of Inorganic and Analytical Chemistry, Poznań University of Medical Sciences, 6 Grunwaldzka St, 60-780 Poznań, Poland.
Sci Total Environ. 2006 Dec 15;372(1):20-31. doi: 10.1016/j.scitotenv.2006.03.030. Epub 2006 May 2.
The levels of organochlorinated pesticides (OCPs): p,p'-DDT and its metabolites, hexachlorobenzene (HCB), hexachlorocyclohexane isomers (HCHs), chlordanes and their metabolites, and 18 polychlorinated biphenyl (PCB) congeners were measured in maternal serum, umbilical cord serum and human milk collected from 22 mothers living in the Wielkopolska region, Poland. Additionally, 11 polybrominated diphenyl ether (PBDE) congeners were measured in the human milk samples. p,p'-DDT and its major metabolite, p,p'-DDE, together with HCB, were found in all milk and serum samples. Median concentrations of p,p'-DDE in maternal serum, umbilical cord serum and milk were 343, 329 and 634ng/g lipid weight (lw). PCB congeners 138, 153 and 180 were the major congeners measured in all serum samples, while CB 170 was detected in 74% and 100% of umbilical cord and maternal serum, respectively. Except for CBs 74, 101 and 105, which had a detection frequency of 77%, 23% and 82%, respectively, all investigated PCB congeners were measured in all human milk samples. The median concentrations of sum PCBs in maternal serum, umbilical cord serum and milk were 79, 60 and 133 ng/g lw, respectively. A good correlation (Spearman R(S)>0.75, p<0.001) was found for major PCBs, p,p'-DDT and p,p'-DDE, between maternal and umbilical cord serum, while the correlation was weaker between milk and serum. The median of sum PBDEs in human milk was 2.0 ng/g lw (range 0.8 to 8.4), with BDE 47 being always the most abundant PBDE congener and, together with BDE 153, being present in all samples. In general, results found in the investigated group are at the low end of the concentration range measured in Europe.
在从波兰大波兰地区居住的22位母亲采集的母血、脐带血血清和母乳中，测定了有机氯农药（OCPs）：p,p'-滴滴涕及其代谢物、六氯苯（HCB）、六氯环己烷异构体（HCHs）、氯丹及其代谢物，以及18种多氯联苯（PCB）同系物的含量。此外，还在母乳样本中测定了11种多溴二苯醚（PBDE）同系物的含量。在所有的母乳和血清样本中均检测到了p,p'-滴滴涕及其主要代谢物p,p'-二氯二苯乙烯（p,p'-DDE）以及六氯苯。母血、脐带血血清和母乳中p,p'-二氯二苯乙烯的中位浓度分别为343、329和634纳克/克脂重（lw）。PCB同系物138、153和180是所有血清样本中检测到的主要同系物，而CB 170分别在74%的脐带血血清和100%的母血中被检测到。除了CBs 74、101和105的检测频率分别为77%、23%和82%外，所有研究的PCB同系物均在所有母乳样本中被检测到。母血、脐带血血清和母乳中多氯联苯总量的中位浓度分别为79、60和133纳克/克脂重。在母血和脐带血血清中，主要的多氯联苯、p,p'-滴滴涕和p,p'-二氯二苯乙烯之间存在良好的相关性（Spearman R(S)>0.75，p<0.001），而母乳和血清之间的相关性较弱。母乳中多溴二苯醚总量的中位值为2.0纳克/克脂重（范围为0.8至8.4），其中BDE 47始终是含量最丰富的多溴二苯醚同系物，并且与BDE 153一起存在于所有样本中。总体而言，在被调查群体中发现的结果处于欧洲测量浓度范围的低端。
