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股骨成形术——用复合骨水泥增强股骨近端——可行性、生物力学特性及骨合成潜力。

Femoroplasty--augmentation of the proximal femur with a composite bone cement--feasibility, biomechanical properties and osteosynthesis potential.

作者信息

Beckmann J, Ferguson S J, Gebauer M, Luering C, Gasser B, Heini P

机构信息

Orthopaedic Clinic and Policlinic of the University of Regensburg, Asklepios Klinik Bad Abbach, Kaiser-Karl-V-Allee 3, 93077 Bad Abbach, Germany.

出版信息

Med Eng Phys. 2007 Sep;29(7):755-64. doi: 10.1016/j.medengphy.2006.08.006. Epub 2006 Oct 4.

DOI:10.1016/j.medengphy.2006.08.006
PMID:17023189
Abstract

BACKGROUND

Analogous to vertebroplasty, cement-augmentation of the proximal femur ("femoroplasty") could reinforce osteoporotic bones. This study was to evaluate (i) the feasibility of femoroplasty with a composite cement (Cortoss), (ii) its influence on femoral strength by mechanical testing and (iii) the feasibility of stable osteosynthesis of the augmented fractured bones.

METHODS

Nine human cadaveric femora were augmented with a composite bone cement, the surface heat generation monitored, and then tested biomechanically against their native contralateral control to determine fracture strength. Subsequently, thirteen reinforced and fractured femora were osteosynthetized by different implants and tested against their osteosynthetisized, non-augmented contralateral control.

FINDINGS

Cement could be injected easily, with a moderate temperature rise. A positive correlation between BMD and fracture load and a significant increase in fracture load (+43%) of the augmented femora compared to their native controls (6324 N and 4430 N, respectively) as well as a significant increase in energy-to-failure (+187%, 86 N m and 30 N m, respectively) was found. Osteosynthesis was possible in cement-augmented femora. Osteosynthetisized femora showed equivalent strength to the intact controls.

INTERPRETATION

Augmentation of the proximal femur with composite bone cement could be of use in prophylaxis of fractures in osteoporotic femurs. Osteosynthesis of the fractured augmented bones is a challenging procedure but has a good chance to restore strength.

摘要

背景

与椎体成形术类似,股骨近端骨水泥强化术(“股骨成形术”)可增强骨质疏松性骨。本研究旨在评估:(i)使用复合骨水泥(Cortoss)进行股骨成形术的可行性;(ii)通过力学测试评估其对股骨强度的影响;(iii)增强后的骨折骨实现稳定骨合成的可行性。

方法

对九具人尸体股骨使用复合骨水泥进行强化,监测表面产热情况,然后与对侧未处理的对照股骨进行生物力学测试以确定骨折强度。随后,对13根强化并骨折的股骨采用不同植入物进行骨合成,并与对侧未强化但进行了骨合成的对照股骨进行测试。

结果

骨水泥易于注射,温度适度升高。骨密度与骨折载荷呈正相关,与未处理的对照股骨相比,强化后的股骨骨折载荷显著增加(分别为6324 N和4430 N,增加了43%),且破坏能量也显著增加(分别为86 N·m和30 N·m,增加了187%)。在骨水泥强化的股骨中可以进行骨合成。骨合成后的股骨显示出与完整对照股骨相当的强度。

解读

使用复合骨水泥强化股骨近端可用于预防骨质疏松性股骨骨折。对强化后的骨折骨进行骨合成是一项具有挑战性的操作,但有很大机会恢复其强度。

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