Sie Mark P S, Uitterlinden André G, Bos Michiel J, Arp Pascal P, Breteler Monique M B, Koudstaal Peter J, Pols Huibert A P, Hofman Albert, van Duijn Cornelia M, Witteman Jacqueline C M
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
Stroke. 2006 Nov;37(11):2667-71. doi: 10.1161/01.STR.0000244779.30070.1a. Epub 2006 Oct 5.
Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cardiovascular and cerebrovascular complications. Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine with a central role in inflammation. Little is known of the relation of variations within the gene and risk of cardiovascular and cerebrovascular disease. We therefore investigated 5 polymorphisms in the TGF-beta1 gene (-800 G/A, -509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study.
Participants (N=6456) of the Rotterdam Study were included in the current study. Analyses of the relations of genotypes with the risk of myocardial infarction and stroke were performed according to Cox proportional-hazards methods. All analyses were adjusted for age, sex, conventional cardiovascular risk factors, and medical history.
We found no association with the risk of myocardial infarction. A significantly increased risk of stroke was found, associated with the T allele of the -509 C/T polymorphism (relative risk, 1.26; (95% CI, 1.06 to 1.49) and the Pro variant of the codon 10 polymorphism (relative risk, 1.24; 95% CI, 1.04 to 1.48).
No association between the TGF-beta1 polymorphisms and myocardial infarction was observed; however, the -509 C/T and codon 10 Leu/Pro polymorphisms were associated with the risk of stroke.
炎症在动脉粥样硬化以及心血管和脑血管并发症的发病机制中起关键作用。转化生长因子-β1（TGF-β1）是一种多效性细胞因子，在炎症中起核心作用。关于该基因变异与心血管和脑血管疾病风险的关系知之甚少。因此，我们在一项基于人群的研究中调查了TGF-β1基因的5个多态性（-800 G/A、-509 C/T、密码子10 Leu/Pro、密码子25 Arg/Pro和密码子263 Thr/Ile）与心肌梗死和中风风险的关系。
鹿特丹研究的参与者（N = 6456）纳入本研究。根据Cox比例风险法分析基因型与心肌梗死和中风风险的关系。所有分析均对年龄、性别、传统心血管危险因素和病史进行了校正。
我们未发现与心肌梗死风险相关。发现中风风险显著增加，与-509 C/T多态性的T等位基因（相对风险，1.26；95%可信区间，1.06至1.49）和密码子10多态性的Pro变体（相对风险，1.24；95%可信区间，1.04至1.48）相关。
未观察到TGF-β1多态性与心肌梗死之间存在关联；然而，-509 C/T和密码子10 Leu/Pro多态性与中风风险相关。
