Le Duc Son N T, Pannacciulli Nicola, Chen Kewei, Del Parigi Angelo, Salbe Arline D, Reiman Eric M, Krakoff Jonathan
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology & Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85016, USA.
Am J Clin Nutr. 2006 Oct;84(4):725-31. doi: 10.1093/ajcn/84.4.725.
In an exploratory positron emission tomography study of postprandial regional cerebral blood flow, which is a marker of neuronal activity, obese men differed from lean men in several brain regions, including the prefrontal cortex. The subjects received a meal proportional to their body size; therefore, the meal volume was different for each person.
We investigated whether differences in the brain responses of obese and lean men to a meal represent satiety or feelings of gastric distension.
We studied 9 lean (x +/- SD body fat: 15 +/- 5%; age: 33 +/- 10 y) and 9 obese (body fat: 31 +/- 4%; age: 32 +/- 10 y) men given a fixed amount (400 mL) of a liquid meal. We compared their results with those in 11 lean (body fat: 16 +/- 5%; age: 35 +/- 8 y) and 11 obese (body fat: 33 +/- 5%; age: 28 +/- 5 y) previously studied men given a meal proportional to their body size. We performed analyses by using a two-level, random-effects approach in the STATISTICAL PARAMETRIC MAPPING software package and a significance level of P < or = 0.001, uncorrected for multiple comparisons.
Compared with lean men, obese men had consistently less postprandial activation in the left dorsolateral prefrontal cortex, irrespective of meal size.
Because the dorsolateral prefrontal cortex has been implicated in the inhibition of inappropriate behavior, satiety, and meal termination, differential responses of neuronal activity to food intake in this area may contribute to a propensity for obesity or to the difficulty in losing weight experienced by obese men.
在一项关于餐后局部脑血流（神经元活动的一个指标）的探索性正电子发射断层扫描研究中，肥胖男性与瘦男性在包括前额叶皮质在内的几个脑区存在差异。受试者接受了与他们身体大小成比例的一餐；因此，每个人的进餐量不同。
我们调查了肥胖和瘦男性对一餐的脑反应差异是代表饱腹感还是胃扩张的感觉。
我们研究了9名瘦男性（体脂x±标准差：15±5%；年龄：33±10岁）和9名肥胖男性（体脂：31±4%；年龄：32±10岁），给他们提供固定量（400毫升）的流食。我们将他们的结果与之前研究的11名瘦男性（体脂：16±5%；年龄：35±8岁）和11名肥胖男性（体脂：33±5%；年龄：28±5岁）的结果进行了比较，这些男性接受的是与他们身体大小成比例的一餐。我们使用统计参数映射软件包中的两级随机效应方法进行分析，显著性水平为P≤0.001，未对多重比较进行校正。
与瘦男性相比，无论进餐量大小，肥胖男性餐后左侧背外侧前额叶皮质的激活一直较少。
由于背外侧前额叶皮质与抑制不适当行为、饱腹感和进餐终止有关，该区域神经元活动对食物摄入的不同反应可能导致肥胖倾向或肥胖男性减肥困难。
