Lichtenberger L M
Department of Integrative Biology, Pharmacology and Physiology, The University of Texas Medical School at Houston, Houston, Texas 77030, USA.
Curr Opin Gastroenterol. 1999 Nov;15(6):463-72. doi: 10.1097/00001574-199911000-00003.
Research performed in the laboratory and the clinic over the past several years has added to our understanding of the mechanisms that are operative in protecting the epithelial lining of the stomach and duodenum from injury and ulceration, most frequently caused by necrotic agents in the lumen. The defensive mechanism of the gastroduodenal mucosa comprises a series of physical, chemical, biologic, and immunologic barriers or mechanisms that act in concert to either prevent or limit cellular injury or transformation. The field of gastroduodenal defense can be subdivided into the following four areas: extracellular mucus barrier properties; membrane and ion transport properties; cellular factors promoting growth and restitution; and vascular, neural, and inflammatory factors ensuring optimal tissue perfusion and immune responsiveness, respectively. In addition, a great deal can be learned about gastroduodenal defense by studying the effects of ulcerogenic factors and conditions on the defensive mechanisms described here and specifically how they may be compromised by nonsteroidal anti-inflammatory drugs and Helicobacter pylori infection. This review presents interesting and noteworthy findings impacting on these properties contributing to gastroduodenal defense since the prior review article on this subject appearing in this journal.
过去几年在实验室和临床进行的研究，增进了我们对胃和十二指肠上皮 lining 免受损伤和溃疡（最常见于由管腔内坏死因子引起）的作用机制的理解。胃十二指肠黏膜的防御机制包括一系列物理、化学、生物和免疫屏障或机制，它们协同作用以预防或限制细胞损伤或转化。胃十二指肠防御领域可细分为以下四个方面：细胞外黏液屏障特性；膜和离子转运特性；促进生长和修复的细胞因子；以及分别确保最佳组织灌注和免疫反应性的血管、神经和炎症因子。此外，通过研究致溃疡因素和条件对本文所述防御机制的影响，特别是它们如何被非甾体抗炎药和幽门螺杆菌感染所损害，可以深入了解胃十二指肠防御。本综述呈现了自该杂志上一篇关于此主题的综述文章发表以来，对这些有助于胃十二指肠防御的特性产生影响的有趣且值得关注的发现。
