Comparative analysis of the interaction of HSPs in dendritic cells, macrophages, RGM-1 cells infected by .

may cause chronic gastritis, even gastric cancer, however, antigen-presenting cells (APCs) are most important immune cells involved in the induction and expression of the underlying inflammatory responses to resist . To study the interaction of HSPs in dendritic cells (DCs), macrophages and RGM-1 cells infected with , HSP-27, HSP-60, HSP-70 and HSP-90 proteins were analyzed in the mucosa tissue or serum of gastritis patients caused by , and in cell supernatant of DCs, macrophages, RGM-1 infected by , or in above host cells. We found that HSP-27, HSP-60, HSP-70 and HSP-90 decreased in gastric epithelial cells, but increased significantly in DCs, macrophages. Meanwhile, inflammation associated proteins iNOS-2 and COX-2 were participated in the expression of HSPs in the process of host cells defensing against infection. These findings contribute to understand the functions of HSP-27, HSP-60, HSP-70 and HSP-90 in infection APCs and gastric epithelial cells indicating that HSPs would be diagnostic markers for infection.