新型肽类抗生素EM49。IV. EM49的结构。
EM49, a new peptide antibiotic IV. The structure of EM49.
作者信息
Parker W L, Rathnum M L
出版信息
J Antibiot (Tokyo). 1975 May;28(5):379-89. doi: 10.7164/antibiotics.28.379.
PMID:170240
Abstract
EM49 is a family of similar peptide antibiotics, each an octapeptide acylated with a beta-hydroxy fatty acid. This paper described the determination of the structure of the fatty acyl residue, the selective removal of this residue from the peptide portion of the molecule, and the sequential analysis of the peptide by the EDMAN method. The structure of EM49, 1, is derived by this degradation.
摘要
EM49是一类相似的肽抗生素家族，每个都是由β-羟基脂肪酸酰化的八肽。本文描述了脂肪酰基残基结构的测定、该残基从分子肽部分的选择性去除，以及通过埃德曼法对肽的序列分析。通过这种降解得到了EM49（1）的结构。
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