Dubrovskaya N M, Nalivaeva N N, Turner A J, Zhuravin I A
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Neurosci Behav Physiol. 2006 Nov;36(9):911-3. doi: 10.1007/s11055-006-0106-9.
Intracortical administration of 10(-4) M batimastat, a specific inhibitor of alpha-secretase (a metalloproteinase which cleaves the amyloid peptide precursor), decreased the number of correct runs in a single-level eight-arm maze to 92.78 +/- 1.03% compared with baseline (p < 0.01) within 60 min. However, injection of batimastat into the cerebral cortex of animals during the early postnatal period (days 5 and 7 of life) led to impaired orientation in the simple single-level maze when these adults reached adulthood (90.92 +/- 2.21% correct runs, p < 0.001) as compared with controls. The data obtained here provide evidence for the important role of alpha-secretase in memory processes. The possible role of alpha-secretase in memory processes and the pathogenesis of Alzheimer's disease is discussed.
α-分泌酶（一种切割淀粉样肽前体的金属蛋白酶）的特异性抑制剂巴马司他以10(-4) M的浓度进行皮质内给药，在60分钟内，单水平八臂迷宫中正确运行的次数与基线相比降至92.78±1.03%（p < 0.01）。然而，在出生后早期（出生后第5天和第7天）向动物的大脑皮质注射巴马司他，当这些动物成年后，在简单的单水平迷宫中的定向能力受损（正确运行次数为90.92±2.21%，p < 0.001），与对照组相比。此处获得的数据为α-分泌酶在记忆过程中的重要作用提供了证据。讨论了α-分泌酶在记忆过程和阿尔茨海默病发病机制中的可能作用。
