Coote J H
Department of Physiology, University of Birmingham Medical School, England.
J Cardiovasc Pharmacol. 1990;15 Suppl 7:S35-41.
The anatomy, physiology, and pharmacology of bulbospinal 5-HT neurons innervating spinal sympathetic cell groups are reviewed. On the basis of the location of 5-HT cell bodies, size of axons, type of synapse, and diversity of chemical coding, it is argued that the group of bulbospinal neurons is anatomically heterogenous. The evidence for both sympathoexcitatory and sympathoinhibitory actions of these neurons is discussed, and, although unequivocal evidence is still lacking, the idea of a functional heterogeneity is attractive. This is supported by observations that 5-HT also has both sympathoexcitatory and sympathoinhibitory actions in the spinal cord. These actions are mediated via two receptors, 5-HT1-like and 5-HT2, respectively. The question of whether or not these receptors are tonically activated is discussed, and it is shown that most evidence indicates they are not.
本文综述了支配脊髓交感神经细胞群的延髓脊髓5-羟色胺（5-HT）能神经元的解剖学、生理学及药理学。基于5-HT细胞体的位置、轴突大小、突触类型及化学编码的多样性，有观点认为延髓脊髓神经元群在解剖学上具有异质性。文中讨论了这些神经元产生交感兴奋和交感抑制作用的证据，尽管仍缺乏明确证据，但功能异质性的观点很有吸引力。脊髓中5-HT也具有交感兴奋和交感抑制作用的观察结果支持了这一观点。这些作用分别通过两种受体介导，即5-HT1样受体和5-HT2受体。文中讨论了这些受体是否持续被激活的问题，结果表明大多数证据表明它们并未持续被激活。
