Rayapuram Naganand, Subramani Suresh
Section of Molecular Biology, Division of Biological Sciences, University of California, San Diego, Room 3230 Bonner Hall, 9500 Gilman Drive, UC San Diego, La Jolla, CA 92093-0322, USA.
Biochim Biophys Acta. 2006 Dec;1763(12):1613-9. doi: 10.1016/j.bbamcr.2006.08.035. Epub 2006 Aug 30.
The import of proteins into the peroxisome matrix is an essential step in peroxisome biogenesis, which is critical for normal functioning of most eukaryotic cells. The translocation of proteins across the peroxisome membrane and the dynamic behavior of the import receptors during the import cycle is facilitated by several peroxisome-membrane-associated protein complexes, one of which is called the importomer complex [B. Agne, N.M. Meindl, K. Niederhoff, H. Einwachter, P. Rehling, A. Sickmann, H.E. Meyer, W. Girzalsky, W.H. Kunau, Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery, Mol. Cell 11 (2003) 635-646; P.P. Hazra, I. Suriapranata, W.B. Snyder, S. Subramani, Peroxisome remnants in pex3Delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes, Traffic 3 (2002) 560-574. ]. We provide below a brief historical perspective regarding the importomer and its role in peroxisome biogenesis. We also identify areas in which further work is needed to uncover the physiological role of the importomer.
蛋白质导入过氧化物酶体基质是过氧化物酶体生物发生的关键步骤，对大多数真核细胞的正常功能至关重要。几种与过氧化物酶体膜相关的蛋白质复合物促进了蛋白质穿过过氧化物酶体膜的转运以及导入循环中导入受体的动态行为，其中一种复合物称为导入体复合物[B. 阿涅、N.M. 迈因德尔、K. 尼德霍夫、H. 艾因瓦赫特、P. 雷林、A. 西克曼、H.E. 迈耶、W. 吉尔扎尔斯基、W.H. 库瑙，Pex8p：过氧化物酶体导入机制的过氧化物酶体内组织者，《分子细胞》11 (2003) 635 - 646；P.P. 哈兹拉、I. 苏里亚普拉纳塔、W.B. 斯奈德、S. 苏布拉马尼，pex3Delta细胞中的过氧化物酶体残余物以及Pex3p对过氧化物酶体对接和转位子复合物之间相互作用的需求，《交通》3 (2002) 560 - 574]。我们在下面提供关于导入体及其在过氧化物酶体生物发生中作用的简要历史回顾。我们还确定了需要进一步开展工作以揭示导入体生理作用的领域。
