Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Nat Cell Biol. 2017 Aug;19(8):876-882. doi: 10.1038/ncb3579. Epub 2017 Jul 17.
Understanding organelle biogenesis is a central focus of cell biology. Whereas some are generated from existing organelles, others can be generated de novo. Most de novo organelle biogenesis occurs in the endoplasmic reticulum (ER). Here, we review the role of the ER in the generation of peroxisomes, lipid droplets, and omegasomes, which are platforms for autophagosome production, and discuss how ER subdomains with specific protein and lipid composition form and promote organelle biogenesis.
了解细胞器的生物发生是细胞生物学的一个核心焦点。有些细胞器是由现有细胞器产生的，而有些则可以从头生成。大多数从头开始的细胞器生物发生发生在内质网 (ER) 中。在这里，我们回顾了 ER 在过氧化物酶体、脂滴和 omegasomes 的生成中的作用，这些都是自噬体产生的平台，并讨论了具有特定蛋白质和脂质组成的 ER 亚区如何形成和促进细胞器的生物发生。
