Geiduschek E Peter, Kassavetis George A
Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0634, USA.
Curr Biol. 2006 Oct 10;16(19):R849-51. doi: 10.1016/j.cub.2006.08.071.
Under growth-limiting conditions, budding yeast shut down transcription of genes of the translation apparatus. Recent studies have shown that this response is signaled, in part, by multiple pathways that converge on Maf1, leading to a change of this protein's phosphorylation state and its relocation to the nucleus, where it represses RNA polymerase III.
在生长受限的条件下，出芽酵母会关闭翻译装置相关基因的转录。最近的研究表明，这种反应部分是由多条汇聚于Maf1的信号通路所介导的，导致该蛋白的磷酸化状态发生变化并转移至细胞核，在细胞核中它会抑制RNA聚合酶III。
