Goel Gautam, Chou I-Chun, Voit Eberhard O
The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, 313 Ferst Drive, Suite 4103, Atlanta, GA 30332-0535, USA.
J Biomol Tech. 2006 Sep;17(4):252-69.
It is proposed that computational systems biology should be considered a biomolecular technique of the twenty-first century, because it complements experimental biology and bioinformatics in unique ways that will eventually lead to insights and a depth of understanding not achievable without systems approaches. This article begins with a summary of traditional and novel modeling techniques. In the second part, it proposes concept map modeling as a useful link between experimental biology and biological systems modeling and analysis. Concept map modeling requires the collaboration between biologist and modeler. The biologist designs a regulated connectivity diagram of processes comprising a biological system and also provides semi-quantitative information on stimuli and measured or expected responses of the system. The modeler converts this information through methods of forward and inverse modeling into a mathematical construct that can be used for simulations and to generate and test new hypotheses. The biologist and the modeler collaboratively interpret the results and devise improved concept maps. The third part of the article describes software, BST-Box, supporting the various modeling activities.
有人提出，计算系统生物学应被视为21世纪的一种生物分子技术，因为它以独特的方式补充了实验生物学和生物信息学，最终将带来一些见解以及一种深度理解，而这些是没有系统方法就无法实现的。本文首先总结了传统和新颖的建模技术。在第二部分，它提出概念图建模作为实验生物学与生物系统建模及分析之间的有用联系。概念图建模需要生物学家和建模者之间的合作。生物学家设计一个由构成生物系统的过程组成的调节连接图，并还提供有关刺激以及系统的测量或预期响应的半定量信息。建模者通过正向和反向建模方法将此信息转换为一个数学结构，该结构可用于模拟以及生成和测试新的假设。生物学家和建模者共同解释结果并设计改进的概念图。文章的第三部分描述了支持各种建模活动的软件BST-Box。
