Voit Eberhard O
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Wiley Interdiscip Rev Syst Biol Med. 2017 Nov;9(6). doi: 10.1002/wsbm.1391. Epub 2017 May 19.
Biochemical systems are among of the oldest application areas of mathematical modeling. Spanning a time period of over one hundred years, the repertoire of options for structuring a model and for formulating reactions has been constantly growing, and yet, it is still unclear whether or to what degree some models are better than others and how the modeler is to choose among them. In fact, the variety of options has become overwhelming and difficult to maneuver for novices and experts alike. This review outlines the metabolic model design process and discusses the numerous choices for modeling frameworks and mathematical representations. It tries to be inclusive, even though it cannot be complete, and introduces the various modeling options in a manner that is as unbiased as that is feasible. However, the review does end with personal recommendations for the choices of default models. WIREs Syst Biol Med 2017, 9:e1391. doi: 10.1002/wsbm.1391 For further resources related to this article, please visit the WIREs website.
生化系统是数学建模最古老的应用领域之一。在长达一百多年的时间里，构建模型和拟定反应的选项不断增加，然而，目前仍不清楚某些模型是否更好或在何种程度上更好，以及建模者应如何在它们之间进行选择。事实上，选项的多样性已变得势不可挡，无论是新手还是专家都难以应对。本综述概述了代谢模型设计过程，并讨论了建模框架和数学表示的众多选择。尽管无法做到全面，但它力求涵盖所有内容，并以尽可能公正的方式介绍各种建模选项。不过，该综述最后还是给出了关于默认模型选择的个人建议。《WIREs系统生物学与医学》2017年第9期，e1391。doi:10.1002/wsbm.1391 有关本文的更多资源，请访问WIREs网站。
