Zhang Li, Mitchell Hazel
The School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.
Drugs Today (Barc). 2006 Sep;42(9):605-16. doi: 10.1358/dot.2006.42.9.1025694.
The etiology of inflammatory bowel disease (IBD) is currently unknown. Although there is convincing evidence supporting a critical role for micro-organisms in the pathogenesis of IBD, the specific organisms involved remain undetermined. Mucus-associated bacteria have recently been considered as likely candidates for involvement in IBD; indeed several mucus-associated bacteria species have been shown to induce IBD-like conditions in animal models, and some of these bacteria have been detected in human intestinal tissues. Further studies are required to investigate the possible role of mucus-associated bacteria in human IBD.
炎症性肠病（IBD）的病因目前尚不清楚。尽管有确凿证据支持微生物在IBD发病机制中起关键作用，但具体涉及的微生物仍未确定。黏液相关细菌最近被认为可能参与IBD；事实上，已显示几种黏液相关细菌物种可在动物模型中诱发类似IBD的病症，并且在人类肠道组织中检测到了其中一些细菌。需要进一步研究以调查黏液相关细菌在人类IBD中的可能作用。
