Tanner J M, Whitehouse R H
J Clin Endocrinol Metab. 1975 Oct;41(4):788-90. doi: 10.1210/jcem-41-4-788.
Nineteen boys with true isolated growth hormone deficiency developed the first stages of puberty at an average bone age of 12.0"years" (Tanner Whitehouse Method 2, RUS score). The average chronological age was 15.0 years. Seven similar girls entered puberty at 10.9"years" in bone age and 13.7 years in chronological age. The means and ranges of bone age at beginning of puberty of these patients are very close to those of normal children.
19名真正的孤立性生长激素缺乏症男孩在平均骨龄12.0岁（坦纳-怀特豪斯方法2，RUS评分）时进入青春期第一阶段。平均实际年龄为15.0岁。7名类似的女孩骨龄10.9岁、实际年龄13.7岁时进入青春期。这些患者青春期开始时的骨龄均值和范围与正常儿童非常接近。
