King Charles H, Sturrock Robert F, Kariuki H Curtis, Hamburger Joseph
Center for Global Health and Diseases, Case Western Reserve University, Wolstein 4126, 10900 Euclid Avenue, Cleveland, OH 44106-7286, USA.
Trends Parasitol. 2006 Dec;22(12):575-82. doi: 10.1016/j.pt.2006.09.006. Epub 2006 Oct 9.
Current population-based schistosomiasis treatment programs are a first step to reducing the global burden of Schistosoma-related disease; however, they might not dramatically reduce parasite transmission in highly endemic areas. Consequently, the benefits of these programs remain in doubt because recurring low-level reinfection is likely to be associated with subtle but persistent morbidities such as anemia, undernutrition and diminished performance status. The real health benefits of transmission control need to be reconsidered and attention given to more aggressive and, ultimately, more affordable parasite elimination strategies. The next generation of schistosomiasis control can be optimized using new monitoring tools and effective transmission containment.
当前基于人群的血吸虫病治疗项目是减轻全球血吸虫相关疾病负担的第一步;然而,在血吸虫病高度流行地区,这些项目可能无法显著减少寄生虫传播。因此,这些项目的益处仍存疑问,因为反复的低水平再感染可能与贫血、营养不良和身体机能下降等轻微但持续的疾病有关。需要重新审视传播控制对健康的实际益处,并关注更积极且最终更经济实惠的寄生虫消除策略。利用新的监测工具和有效的传播遏制措施,可以优化下一代血吸虫病控制。