Keenan Michael J, Zhou Jun, McCutcheon Kathleen L, Raggio Anne M, Bateman H Gale, Todd Emily, Jones Christina K, Tulley Richard T, Melton Sheri, Martin Roy J, Hegsted Maren
Human Nutrition and Food Division, School of Human Ecology, Louisiana State University Agriculture Center, Baton Rouge, LA 70803, USA.
Obesity (Silver Spring). 2006 Sep;14(9):1523-34. doi: 10.1038/oby.2006.176.
To assess the effects of energy dilution with non-fermentable and fermentable fibers on abdominal fat and gut peptide YY (PYY) and glucagon-like peptide (GLP)-1 expressions, three rat studies were conducted to: determine the effects of energy dilution with a non-fermentable fiber, compare similar fiber levels of fermentable and non-fermentable fibers, and compare similar metabolizable energy dilutions with fermentable and non-fermentable fibers.
In Study 1, rats were fed one of three diets with different metabolizable energy densities. In Study 2, rats were fed diets with similar fiber levels using high amylose-resistant cornstarch (RS) or methylcellulose. In Study 3, rats were fed diets with a similar dilution of metabolizable energy using cellulose or RS. Measurements included food intake, body weight, abdominal fat, plasma PYY and GLP-1, gastrointestinal tract weights, and gene transcription of PYY and proglucagon.
Energy dilution resulted in decreased abdominal fat in all studies. In Study 2, rats fed fermentable RS had increased cecal weights and plasma PYY and GLP-1, and increased gene transcription of PYY and proglucagon. In Study 3, RS-fed rats had increased short-chain fatty acids in cecal contents, plasma PYY (GLP-1 not measured), and gene transcription for PYY and proglucagon.
Inclusion of RS in the diet may affect energy balance through its effect as a fiber or a stimulator of PYY and GLP-1 expression. Increasing gut hormone signaling with a bioactive functional food such as RS may be an effective natural approach to the treatment of obesity.
为评估不可发酵纤维和可发酵纤维进行能量稀释对腹部脂肪、肠道肽YY（PYY）和胰高血糖素样肽（GLP）-1表达的影响，开展了三项大鼠研究，以：确定不可发酵纤维进行能量稀释的效果，比较可发酵纤维和不可发酵纤维的相似纤维水平，以及比较可发酵纤维和不可发酵纤维的相似可代谢能量稀释情况。
在研究1中，给大鼠喂食三种具有不同可代谢能量密度的饮食之一。在研究2中，给大鼠喂食使用高直链抗性玉米淀粉（RS）或甲基纤维素的具有相似纤维水平的饮食。在研究3中，给大鼠喂食使用纤维素或RS的具有相似可代谢能量稀释的饮食。测量指标包括食物摄入量、体重、腹部脂肪、血浆PYY和GLP-1、胃肠道重量以及PYY和胰高血糖素原的基因转录。
在所有研究中，能量稀释均导致腹部脂肪减少。在研究2中，喂食可发酵RS的大鼠盲肠重量增加，血浆PYY和GLP-1增加，PYY和胰高血糖素原的基因转录增加。在研究3中，喂食RS的大鼠盲肠内容物中的短链脂肪酸增加，血浆PYY（未测量GLP-1）以及PYY和胰高血糖素原的基因转录增加。
饮食中添加RS可能通过其作为纤维的作用或作为PYY和GLP-1表达的刺激物来影响能量平衡。用RS等生物活性功能食品增加肠道激素信号传导可能是治疗肥胖症的一种有效的自然方法。
