School of Human Ecology, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA.
Obesity (Silver Spring). 2014 Feb;22(2):344-8. doi: 10.1002/oby.20501. Epub 2013 Oct 15.
Obesity is a health concern. Resistant starch (RS) type 2 from high-amylose maize (HAM-RS2) and dietary sodium butyrate (SB) reduce abdominal fat in rodents. RS treatment is associated with increased gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), but it is not known if SB increases these hormones.
This was investigated in a 2 × 2 rat study with HAM-RS2 (0 or 28% weight) and dietary sodium butyrate (0 and 3.2%) resulting in isocaloric treatments: energy control (EC), sodium butyrate (SB), HAM-RS2 (RS), and the combination (SBRS).
RS and SB reduced abdominal fat and the combination reduced abdominal fat compared to SB and RS. RS was associated with increased fermentation in the cecum. Serum PYY and GLP-1 total were increased with RS treatment. RS treatment was associated with increased cecal butyrate produced from fermentation of RS, but there was no cecal increase for dietary SB.
SB after its absorption into the blood appears to not affect production of PYY and GLP-1, while butyrate from fermentation in the cecum promotes increased PYY and GLP-1. Future studies with lower doses of RS and SB are warranted and the combination may be beneficial for human health.
肥胖是一个健康问题。高直链淀粉玉米（HAM-RS2）中的抗性淀粉（RS）类型 2 和膳食丁酸（SB）可减少啮齿动物腹部脂肪。RS 处理与肠道激素肽 YY（PYY）和胰高血糖素样肽 1（GLP-1）的增加有关，但尚不清楚 SB 是否会增加这些激素。
这是在一项 2×2 大鼠研究中进行的，研究了 HAM-RS2（0 或 28%重量）和膳食丁酸（0 和 3.2%），导致等热量处理：能量对照（EC）、丁酸钠（SB）、高直链淀粉玉米 RS（RS）和组合（SBRS）。
RS 和 SB 减少了腹部脂肪，组合与 SB 和 RS 相比减少了腹部脂肪。RS 与盲肠发酵增加有关。RS 处理与血清 PYY 和 GLP-1 总量增加有关。RS 处理与 RS 发酵产生的盲肠丁酸增加有关，但膳食 SB 对盲肠没有增加。
吸收到血液中的 SB 似乎不会影响 PYY 和 GLP-1 的产生，而来自盲肠发酵的丁酸则促进 PYY 和 GLP-1 的增加。未来需要进行 RS 和 SB 更低剂量的研究，并且组合可能对人类健康有益。
