一种生物相容性的促排方法：双膦酸盐修饰的磁铁矿纳米颗粒用于去除血液中的铀酰离子。

A biocompatible method of decorporation: bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood.

作者信息

Wang Ling, Yang Zhimou, Gao Jinhao, Xu Keming, Gu Hongwei, Zhang Bei, Zhang Xixiang, Xu Bing

机构信息

Departments of Chemistry and Physics, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.

出版信息

J Am Chem Soc. 2006 Oct 18;128(41):13358-9. doi: 10.1021/ja0651355.

DOI:10.1021/ja0651355

PMID:17031939

Abstract

We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.

摘要

我们报道了通过多巴胺（DA）连接使用双膦酸盐对Fe3O4磁性纳米颗粒进行功能化的方法。使用四乙基-3-氨基丙烷-1,1-双膦酸盐（BP）作为功能分子，我们创建了一个具有Fe3O4-DA-BP纳米结构的体系，该体系对从水或血液中去除铀酰离子具有高特异性。这项工作表明，磁性纳米颗粒与特定的受体-配体相互作用相结合，有望为从生物环境中检测、回收和去除金属毒素提供一个灵敏且快速的平台。