Bresciani E, Rapetti D, Donà F, Bulgarelli I, Tamiazzo L, Locatelli V, Torsello A
Department of Experimental Medicine, University of Milano-Bicocca, 20052 Monza (MI), Italy.
J Endocrinol Invest. 2006 Sep;29(8):RC16-8. doi: 10.1007/BF03344175.
Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH and corticosterone secretion. Our results demonstrate that in young-adult male rats, obestatin effectively blunts the hunger caused by short-term starvation. Obestatin did not modify GH secretion in 10-day-old rats and did not antagonize the GH-releasing effects of hexarelin. Moreover, obestatin administration had no effects on spontaneous corticosterone secretion. In conclusion, these data demonstrate that in young-adult male rats the newly discovered obestatin can inhibit feeding but does not modify GH and corticosterone release in infant rats.
肥胖抑制素是一种最近发现的由胃饥饿素基因衍生而来的含23个氨基酸的肽。与胃饥饿素相反，肥胖抑制素被证明可抑制小鼠的食物摄入。本研究的目的是研究急性给予肥胖抑制素对大鼠进食行为的影响及其对生长激素（GH）和皮质酮分泌的影响。我们的结果表明，在年轻成年雄性大鼠中，肥胖抑制素可有效减轻短期饥饿引起的饥饿感。肥胖抑制素对10日龄大鼠的生长激素分泌没有影响，也不拮抗六肽生长激素释放肽的促生长激素释放作用。此外，给予肥胖抑制素对自发性皮质酮分泌没有影响。总之，这些数据表明，在年轻成年雄性大鼠中，新发现的肥胖抑制素可抑制进食，但对幼鼠的生长激素和皮质酮释放没有影响。
