Jacobson Brian C, Van Dam Jacques
Department of Medicine, Harvard Medical School, and Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Curr Opin Gastroenterol. 2002 Sep;18(5):581-6. doi: 10.1097/00001574-200209000-00010.
Endoscopic detection of dysplasia currently requires either the presence of a visible lesion (such as a polyp) or the serendipitous sampling of a dysplastic focus during "blind" surveillance biopsies. To accurately and efficiently examine large areas of mucosa during surveillance endoscopy, new methods are required to render dysplasia visible. Spectroscopy and optical coherence tomography are two technologies under active investigation for this purpose. This review presents the basic concepts behind these technologies and discusses their utility in the detection of gastrointestinal dysplasia.
目前，内镜下检测发育异常需要存在可见病变（如息肉），或者在“盲目”监测活检期间偶然采集到发育异常病灶。为了在监测性内镜检查期间准确、高效地检查大面积黏膜，需要新的方法使发育异常变得可见。光谱学和光学相干断层扫描是目前正在积极研究用于此目的的两种技术。本文综述了这些技术背后的基本概念，并讨论了它们在检测胃肠道发育异常中的应用。
