FK506 作用下原位肝移植术后排斥反应的发生率及治疗情况
Incidence and treatment of rejection episodes in primary orthotopic liver transplantation under FK 506.
作者信息
Jain A B, Fung J J, Todo S, Alessiani M, Takaya S, Abu-Elmagd K, Tzakis A, Starzl T E
机构信息
Department of Surgery, University of Pittsburgh, Pennsylvania.
出版信息
Transplant Proc. 1991 Feb;23(1 Pt 2):928-30.
Abstract
FK 506 therapy with low doses of steroids was adequate to control rejection in most liver recipients. Rejection episodes were readily reversed with single IV doses of methylprednisone or hydrocortisone. Short courses of OKT3 (3 to 5 days 5-10 mL) controlled severe rejections. The rate of retransplantation directly due to rejection was low (1.6%). There was a limited need for steroids either early or out to 6 to 12 months.
摘要
低剂量类固醇的FK 506疗法足以控制大多数肝移植受者的排斥反应。单次静脉注射甲基强的松龙或氢化可的松可迅速逆转排斥反应发作。短疗程的OKT3（3至5天，5 - 10毫升）可控制严重排斥反应。直接因排斥反应导致的再次移植率较低（1.6%）。无论是早期还是术后6至12个月，对类固醇的需求都有限。
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